Myers' Cocktail IV Therapy
The gold standard wellness IV since the 1960s
$149–$275
Per session
45 min
Session duration
7 Benefits
Documented effects
6
Active ingredients

Key Takeaways
- The Myers' Cocktail blends magnesium, calcium, B-complex vitamins, vitamin B12, and vitamin C in a saline base — the original IV vitamin formula, developed by Dr. John Myers in the 1960s.
- A typical session costs $149–$275 and takes about 30–45 minutes.
- It is the most widely used and most-studied wellness IV, but high-quality clinical evidence remains limited — most support comes from a 2002 review and a small 2009 randomized trial.
- Most people use it for fatigue, migraines, fibromyalgia, immune support, and general wellness.
- It is generally well tolerated, but should be avoided by people with kidney disease, high calcium or magnesium levels, or who take digoxin — always complete a medical intake first.
What is Myers' Cocktail IV Therapy?
Developed by Dr. John Myers in the 1960s, the Myers' Cocktail is the most evidence-based IV therapy available. It combines magnesium, calcium, B vitamins, and vitamin C in a balanced saline solution — addressing multiple nutrient deficiencies simultaneously. The go-to drip for overall wellness, fatigue, fibromyalgia, asthma, and general micronutrient support.
How Myers' Cocktail IV Therapy Works
The Myers' Cocktail works on a simple principle: delivering nutrients directly into the bloodstream bypasses the digestive system entirely. When you swallow a vitamin, the gut tightly regulates how much actually reaches your blood — oral vitamin C absorption, for example, plateaus around 200 mg regardless of how much you take. An IV sidesteps that ceiling, producing blood concentrations several times higher than any oral dose and making the full amount immediately available to your cells.
Each component plays a defined role. Magnesium relaxes smooth muscle and is a cofactor in more than 300 enzymatic reactions, which is why it is central to the formula’s use for migraines, muscle tension, and asthma. The B-complex and B12 drive cellular energy metabolism and red-blood-cell and nerve function. Vitamin C acts as an antioxidant and supports immune activity and collagen synthesis. Calcium is included in small amounts to balance the magnesium.
Because the infusion is given slowly over 30–45 minutes rather than as a rapid push, nutrient levels rise in a controlled way and the kidneys clear any excess over the following hours. This is also why a licensed nurse screens your kidney function and medication list first — the same direct delivery that makes IV therapy effective is what makes proper screening important.
What's in a Myers' Cocktail Drip?
| Ingredient | What it does | Typical dose |
|---|---|---|
| Magnesium chloride | Relaxes smooth muscle and is a cofactor in 300+ enzymatic reactions; the key player behind migraine, muscle-tension, and asthma uses. | 1–2 g |
| Calcium gluconate | Balances the magnesium and supports nerve and muscle signaling. | ~0.5 g |
| B-complex (B1, B2, B3, B5, B6) | Cofactors that drive energy metabolism and nervous-system function. | 1 mL |
| Vitamin B12 (methyl- or hydroxocobalamin) | Supports red-blood-cell production, nerve health, and energy. | 1,000 mcg |
| Vitamin C (ascorbic acid) | Antioxidant that supports immune function and collagen synthesis. | 1–10 g |
| Normal saline (0.9% NaCl) | Sterile carrier fluid that also rehydrates and helps deliver the nutrients evenly. | 250–500 mL |
What to Expect During a Myers' Cocktail Session
Your visit starts with a short intake: a clinician reviews your health history, current medications, and goals, and screens for the contraindications below. At a reputable provider this step is non-negotiable.
A nurse then places a small IV catheter, usually in the arm, and starts the drip. The infusion runs for roughly 30–45 minutes while you sit back, read, or work. Many people notice a feeling of warmth and a temporary metallic or vitamin-like taste as the magnesium and B vitamins go in — this is normal and fades quickly. Pushing the drip too fast can cause lightheadedness, so tell your nurse if anything feels off and they will slow the rate.
Afterward there is no downtime — you can drive and return to normal activity immediately. Some people feel an energy or clarity boost the same day; for others the benefit is more subtle and builds with repeat sessions. Frequency is individual, ranging from a one-off pick-me-up to a weekly or monthly cadence guided by your provider.
Benefits of Myers' Cocktail
Who is Myers' Cocktail Best For?
- General wellness
- Chronic fatigue
- Migraine prevention
- Immune support
- Athletic performance
- Fibromyalgia
- Asthma management
Myers' Cocktail IV Therapy Cost
Starts from
$149
Typical high
$275
Session
45 min
What affects Myers' Cocktail pricing?
| Clinic vs. mobile (at-home) service | Mobile visits add a $25–$50 travel fee |
| Add-ons (glutathione, anti-nausea, extra B12) | +$25–$75 each |
| Dose / volume of the infusion | Higher doses sit at the top of the range |
| Membership or multi-session packages | Often 10–25% lower per session |
| Local market & cost of living | Major metros trend higher |
Evidence & Research
The scientific case for the Myers' Cocktail rests mainly on two sources. In 2002, Dr. Alan Gaby published a widely cited review in Alternative Medicine Review describing more than 15 years of clinical use and reporting benefit in conditions including fatigue, migraine, fibromyalgia, and asthma — but this was a narrative review of clinical experience, not a controlled trial.
The best controlled evidence is a 2009 randomized, placebo-controlled pilot study from Yale (Ali and colleagues, Journal of Alternative and Complementary Medicine) in 34 fibromyalgia patients. Both the Myers’ group and the saline-placebo group improved significantly over eight weeks, and the difference between them was not statistically significant. The authors noted the formula was safe and that the strong placebo (and hydration) response made a true effect hard to isolate in such a small sample.
The bottom line: the underlying rationale — that IV delivery achieves nutrient levels oral supplements cannot — is well established (Padayatty and colleagues documented this for vitamin C in 2004). But rigorous, large-scale evidence that the Myers’ Cocktail outperforms placebo for specific conditions is still limited. It is best viewed as a generally safe wellness and micronutrient-replenishment therapy rather than a proven treatment for any disease. Talk to a qualified provider about whether it fits your situation.
Myers' Cocktail vs. Other IV Drips
Myers' Cocktail vs. IV Hydration
IV Hydration guideBasic IV hydration is just saline and electrolytes — faster and cheaper (from ~$99) but with none of the vitamins or minerals in a Myers'. Choose plain hydration for pure rehydration; choose a Myers' when you want micronutrient support too.
Myers' Cocktail vs. NAD+
NAD+ guideNAD+ targets cellular energy, DNA repair, and longevity over a longer (60–90 min) and pricier infusion. The Myers' is a broad, affordable wellness baseline; NAD+ is a specialized anti-aging and cognitive-performance protocol.
Important Considerations
Always disclose the following conditions to your provider before receiving Myers' Cocktail therapy:
- Severe kidney disease
- Hypercalcemia
- Digitalis use (calcium)
- Hypermagnesemia
Myers' Cocktail IV Therapy — FAQs
Sources & References
- Gaby AR. Intravenous nutrient therapy: the “Myers' cocktail.” (2002) — Alternative Medicine Review
- Ali A, Njike VY, et al. Intravenous micronutrient therapy (Myers' Cocktail) for fibromyalgia: a placebo-controlled pilot study. (2009) — Journal of Alternative and Complementary Medicine
- Padayatty SJ, et al. Vitamin C pharmacokinetics: implications for oral and intravenous use. (2004) — Annals of Internal Medicine
- Magnesium — Health Professional Fact Sheet — NIH Office of Dietary Supplements
- Vitamin B12 — Health Professional Fact Sheet — NIH Office of Dietary Supplements
Medical Disclaimer
This content is for informational purposes only and does not constitute medical advice. IV therapy should only be administered by licensed medical professionals. Always consult a qualified healthcare provider before starting any IV therapy treatment.