Myers' Cocktail IV Therapy

The gold standard wellness IV since the 1960s

Medically reviewed by Jonathan Belmore, MD|Updated 2026-06-01

$149$275

Per session

45 min

Session duration

7 Benefits

Documented effects

6

Active ingredients

Myers' Cocktail IV Therapy

Key Takeaways

  • The Myers' Cocktail blends magnesium, calcium, B-complex vitamins, vitamin B12, and vitamin C in a saline base — the original IV vitamin formula, developed by Dr. John Myers in the 1960s.
  • A typical session costs $149–$275 and takes about 30–45 minutes.
  • It is the most widely used and most-studied wellness IV, but high-quality clinical evidence remains limited — most support comes from a 2002 review and a small 2009 randomized trial.
  • Most people use it for fatigue, migraines, fibromyalgia, immune support, and general wellness.
  • It is generally well tolerated, but should be avoided by people with kidney disease, high calcium or magnesium levels, or who take digoxin — always complete a medical intake first.

What is Myers' Cocktail IV Therapy?

Developed by Dr. John Myers in the 1960s, the Myers' Cocktail is the most evidence-based IV therapy available. It combines magnesium, calcium, B vitamins, and vitamin C in a balanced saline solution — addressing multiple nutrient deficiencies simultaneously. The go-to drip for overall wellness, fatigue, fibromyalgia, asthma, and general micronutrient support.

How Myers' Cocktail IV Therapy Works

The Myers' Cocktail works on a simple principle: delivering nutrients directly into the bloodstream bypasses the digestive system entirely. When you swallow a vitamin, the gut tightly regulates how much actually reaches your blood — oral vitamin C absorption, for example, plateaus around 200 mg regardless of how much you take. An IV sidesteps that ceiling, producing blood concentrations several times higher than any oral dose and making the full amount immediately available to your cells.

Each component plays a defined role. Magnesium relaxes smooth muscle and is a cofactor in more than 300 enzymatic reactions, which is why it is central to the formula’s use for migraines, muscle tension, and asthma. The B-complex and B12 drive cellular energy metabolism and red-blood-cell and nerve function. Vitamin C acts as an antioxidant and supports immune activity and collagen synthesis. Calcium is included in small amounts to balance the magnesium.

Because the infusion is given slowly over 30–45 minutes rather than as a rapid push, nutrient levels rise in a controlled way and the kidneys clear any excess over the following hours. This is also why a licensed nurse screens your kidney function and medication list first — the same direct delivery that makes IV therapy effective is what makes proper screening important.

What's in a Myers' Cocktail Drip?

IngredientWhat it doesTypical dose
Magnesium chlorideRelaxes smooth muscle and is a cofactor in 300+ enzymatic reactions; the key player behind migraine, muscle-tension, and asthma uses.1–2 g
Calcium gluconateBalances the magnesium and supports nerve and muscle signaling.~0.5 g
B-complex (B1, B2, B3, B5, B6)Cofactors that drive energy metabolism and nervous-system function.1 mL
Vitamin B12 (methyl- or hydroxocobalamin)Supports red-blood-cell production, nerve health, and energy.1,000 mcg
Vitamin C (ascorbic acid)Antioxidant that supports immune function and collagen synthesis.1–10 g
Normal saline (0.9% NaCl)Sterile carrier fluid that also rehydrates and helps deliver the nutrients evenly.250–500 mL

What to Expect During a Myers' Cocktail Session

Your visit starts with a short intake: a clinician reviews your health history, current medications, and goals, and screens for the contraindications below. At a reputable provider this step is non-negotiable.

A nurse then places a small IV catheter, usually in the arm, and starts the drip. The infusion runs for roughly 30–45 minutes while you sit back, read, or work. Many people notice a feeling of warmth and a temporary metallic or vitamin-like taste as the magnesium and B vitamins go in — this is normal and fades quickly. Pushing the drip too fast can cause lightheadedness, so tell your nurse if anything feels off and they will slow the rate.

Afterward there is no downtime — you can drive and return to normal activity immediately. Some people feel an energy or clarity boost the same day; for others the benefit is more subtle and builds with repeat sessions. Frequency is individual, ranging from a one-off pick-me-up to a weekly or monthly cadence guided by your provider.

Benefits of Myers' Cocktail

Energy boost
Immune support
Migraine relief
Fatigue reduction
Fibromyalgia symptom relief
Asthma symptom support
General micronutrient replenishment

Who is Myers' Cocktail Best For?

  • General wellness
  • Chronic fatigue
  • Migraine prevention
  • Immune support
  • Athletic performance
  • Fibromyalgia
  • Asthma management

Myers' Cocktail IV Therapy Cost

Starts from

$149

Typical high

$275

Session

45 min

What affects Myers' Cocktail pricing?

Clinic vs. mobile (at-home) serviceMobile visits add a $25–$50 travel fee
Add-ons (glutathione, anti-nausea, extra B12)+$25–$75 each
Dose / volume of the infusionHigher doses sit at the top of the range
Membership or multi-session packagesOften 10–25% lower per session
Local market & cost of livingMajor metros trend higher
See the full IV therapy cost guide

Evidence & Research

The scientific case for the Myers' Cocktail rests mainly on two sources. In 2002, Dr. Alan Gaby published a widely cited review in Alternative Medicine Review describing more than 15 years of clinical use and reporting benefit in conditions including fatigue, migraine, fibromyalgia, and asthma — but this was a narrative review of clinical experience, not a controlled trial.

The best controlled evidence is a 2009 randomized, placebo-controlled pilot study from Yale (Ali and colleagues, Journal of Alternative and Complementary Medicine) in 34 fibromyalgia patients. Both the Myers’ group and the saline-placebo group improved significantly over eight weeks, and the difference between them was not statistically significant. The authors noted the formula was safe and that the strong placebo (and hydration) response made a true effect hard to isolate in such a small sample.

The bottom line: the underlying rationale — that IV delivery achieves nutrient levels oral supplements cannot — is well established (Padayatty and colleagues documented this for vitamin C in 2004). But rigorous, large-scale evidence that the Myers’ Cocktail outperforms placebo for specific conditions is still limited. It is best viewed as a generally safe wellness and micronutrient-replenishment therapy rather than a proven treatment for any disease. Talk to a qualified provider about whether it fits your situation.

Myers' Cocktail vs. Other IV Drips

Myers' Cocktail vs. IV Hydration

IV Hydration guide

Basic IV hydration is just saline and electrolytes — faster and cheaper (from ~$99) but with none of the vitamins or minerals in a Myers'. Choose plain hydration for pure rehydration; choose a Myers' when you want micronutrient support too.

Myers' Cocktail vs. NAD+

NAD+ guide

NAD+ targets cellular energy, DNA repair, and longevity over a longer (60–90 min) and pricier infusion. The Myers' is a broad, affordable wellness baseline; NAD+ is a specialized anti-aging and cognitive-performance protocol.

Important Considerations

Always disclose the following conditions to your provider before receiving Myers' Cocktail therapy:

  • Severe kidney disease
  • Hypercalcemia
  • Digitalis use (calcium)
  • Hypermagnesemia

Myers' Cocktail IV Therapy — FAQs

Developed by Dr. John Myers in the 1960s, the Myers' Cocktail is the most evidence-based IV therapy available. It combines magnesium, calcium, B vitamins, and vitamin C in a balanced saline solution — addressing multiple nutrient deficiencies simultaneously. The go-to drip for overall wellness, fatigue, fibromyalgia, asthma, and general micronutrient support.
Myers' Cocktail IV therapy typically costs $149–$275 per session, depending on your location and provider. Some clinics offer package pricing for multiple sessions.
A Myers' Cocktail IV session takes approximately 45 minutes. Add 10–15 minutes for setup and intake at your first visit.
Myers' Cocktail IV therapy is best for: General wellness, Chronic fatigue, Migraine prevention, Immune support, Athletic performance, Fibromyalgia, Asthma management. Consult with the clinical staff if you have existing health conditions.
The following conditions may contraindicate Myers' Cocktail: Severe kidney disease, Hypercalcemia, Digitalis use (calcium), Hypermagnesemia. Always complete the health intake form and disclose all medications and conditions before your session.
No. The individual ingredients (vitamins, minerals, saline) are regulated, but the Myers' Cocktail as a formula is not an FDA-approved drug for treating any specific condition. It is administered off-label as a nutritional therapy by licensed clinicians.
It varies by goal. Some people get one occasionally as a wellness boost; others with chronic fatigue, migraines, or fibromyalgia receive weekly sessions for a period, then taper to monthly maintenance. A provider should tailor frequency to your needs rather than a fixed schedule.
A transient metallic or vitamin-like taste and a flushed, warm sensation are common and harmless — they come from the magnesium and B vitamins entering your bloodstream. They pass within minutes and your nurse can slow the infusion if it feels uncomfortable.
Oral absorption is capped by the gut — for vitamin C it plateaus around 200 mg no matter the dose. An IV bypasses that limit and delivers the full amount to your bloodstream immediately, achieving levels oral supplements cannot reach. For correcting a true deficiency quickly, IV is far more direct.
Some people feel more energy or mental clarity the same day; for others the effect is subtle and builds over several sessions. Hydration alone can account for part of the immediate "lift," so individual responses vary widely.
For most healthy adults it is well tolerated when given by a licensed professional after a proper intake. It should be avoided or used with caution by people with kidney disease, high blood calcium or magnesium, or those taking digoxin. Disclose all conditions and medications before your session.

Sources & References

  1. Gaby AR. Intravenous nutrient therapy: the “Myers' cocktail.” (2002)Alternative Medicine Review
  2. Ali A, Njike VY, et al. Intravenous micronutrient therapy (Myers' Cocktail) for fibromyalgia: a placebo-controlled pilot study. (2009)Journal of Alternative and Complementary Medicine
  3. Padayatty SJ, et al. Vitamin C pharmacokinetics: implications for oral and intravenous use. (2004)Annals of Internal Medicine
  4. Magnesium — Health Professional Fact SheetNIH Office of Dietary Supplements
  5. Vitamin B12 — Health Professional Fact SheetNIH Office of Dietary Supplements

Medical Disclaimer

This content is for informational purposes only and does not constitute medical advice. IV therapy should only be administered by licensed medical professionals. Always consult a qualified healthcare provider before starting any IV therapy treatment.